Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 8, 2025BloodOpen Access

Longitudinal multiproteomic analysis reveals persistent underlying inflammation in acute graft-versus-host disease patients responding to corticosteroid treatment

View Full Paper
Ask AI
Bookmark
Share

Authors

MPMaria Matthaiakaki PanagiotakiSMShane McCarthyTNThomas Norton

Discussion

Loading...

Member takes

Overview

Longitudinal analysis reveals persistent inflammation despite corticosteroid treatment in acute graft-versus-host disease, indicating complex immune responses.

Key Points

  • This research aims to understand the immune responses and inflammation associated with corticosteroid treatment in aGvHD.
  • Conducted a multiproteomic analysis of aGvHD patients pre-HSCT and at aGvHD onset and 30 days post-onset
  • Performed immunophenotyping via flow cytometry on peripheral blood mononuclear cells
  • Analyzed plasma proteomics related to cytokine and immune marker levels.
  • Patients exhibited increased circulating monocytes and myeloid dendritic cells that normalized with corticosteroid treatment
  • Significant elevation of immune markers including Granzyme B and CXCL9 persisted despite treatment
  • 8 out of 10 patients achieved clinical remission after receiving corticosteroids.

Cite This Study

Panagiotaki et al. (2025) studied this question.

synapsesocial.com/papers/69362f714fa91c937236e200https://doi.org/10.1182/blood-2025-2456
View Full Paper
Ask AI
Bookmark
Share