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December 8, 2025Blood

Peripheral plasmablast expansion as a predictor and therapeutic target in chronic GVHD

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Authors

KHKatharina HabenichtAHAndreas HiergeistMFMatthias Fante

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Overview

Prospective study shows plasmablast frequency associated with cGVHD onset in allo-SCT patients, suggesting therapeutic targeting may improve outcomes.

Key Points

  • To investigate the role of plasmablasts in predicting and targeting chronic GVHD following stem cell transplantation.
  • Analyzed peripheral blood samples from 172 allo-SCT patients at specified time points
  • Grouped patients by GVHD status and analyzed plasmablast frequencies using flow cytometry
  • Evaluated the effect of first-line steroid therapy on B cell subpopulations and plasmablast frequencies
  • Patients developing cGVHD had significantly higher plasmablast frequencies at day 90 post-transplant
  • Cox model identified plasmablast frequency >3% as an independent risk factor for cGVHD
  • Steroid therapy reduced plasmablast frequencies and BAFF levels after disease onset

Cite This Study

Habenicht et al. (2025) studied this question.

synapsesocial.com/papers/69362f634fa91c937236ddf4https://doi.org/10.1182/blood-2025-4245
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Longitudinal multiproteomic analysis reveals persistent underlying inflammation in acute graft-versus-host disease patients responding to corticosteroid treatment2025
  2. 2Impact CD34+ cell doses and allograft composition on acute graft-versus-host disease: A single-center prospective cohort study2025
  3. 3Plasma proteins associated with chronic graft-versus-host disease organ involvement2026
  4. 4High donor regulatory B cells (Bregs) and their rapid recovery are associated with protection from the development of acute graft-versus-host disease (aGVHD) following allogeneic hematopoietic stem cell transplantation.2025 · 1 citations
  5. 5Can immune reconstitution parameters be highlighted for chronic graft versus host disease in children one month after HSCT?2024