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December 8, 2025Blood

Impact CD34+ cell doses and allograft composition on acute graft-versus-host disease: A single-center prospective cohort study

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Authors

JÁJosé G. Ávila

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Overview

Cohort study shows higher acute graft-versus-host disease rates with peripheral blood grafts, indicating cell content influences severity.

Key Points

  • To examine how graft composition affects the occurrence and severity of acute graft-versus-host disease (aGVHD) in allo-HSCT recipients.
  • Single-center prospective cohort study of patients undergoing allo-HSCT
  • Analyzed graft composition using flow cytometry to quantify T and B lymphocytes
  • Correlations between CD34+ doses and lymphocyte content assessed with Spearman's correlations
  • GVHD severity categorized using the Gluckberg scale
  • 44.8% aGVHD rate observed in the cohort
  • Larger B-cell doses related to aGVHD severity (p=0.048)
  • No significant association found between stem cell source and aGVHD frequency or severity

Cite This Study

José G. Ávila (2025) studied this question.

synapsesocial.com/papers/69362f3a4fa91c937236d416https://doi.org/10.1182/blood-2025-7759
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