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December 8, 2025Blood

Impact CD34+ cell doses and allograft composition on acute graft-versus-host disease: A single-center prospective cohort study

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Authors

JÁJosé G. Ávila

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Overview

Cohort study shows higher acute graft-versus-host disease rates with peripheral blood grafts, indicating cell content influences severity.

Key Points

  • To examine how graft composition affects the occurrence and severity of acute graft-versus-host disease (aGVHD) in allo-HSCT recipients.
  • Single-center prospective cohort study of patients undergoing allo-HSCT
  • Analyzed graft composition using flow cytometry to quantify T and B lymphocytes
  • Correlations between CD34+ doses and lymphocyte content assessed with Spearman's correlations
  • GVHD severity categorized using the Gluckberg scale
  • 44.8% aGVHD rate observed in the cohort
  • Larger B-cell doses related to aGVHD severity (p=0.048)
  • No significant association found between stem cell source and aGVHD frequency or severity

Cite This Study

José G. Ávila (2025) studied this question.

synapsesocial.com/papers/69362f3a4fa91c937236d416https://doi.org/10.1182/blood-2025-7759
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1To determine correlation of CD3+ T cells infusion dose with Acute Graft Versus Host Disease (GVHD) in patients undergoing Allogeneic Hematopoietic Stem Cell Transplantation (HSCT).2024
  2. 2High donor regulatory B cells (Bregs) and their rapid recovery are associated with protection from the development of acute graft-versus-host disease (aGVHD) following allogeneic hematopoietic stem cell transplantation.2025 · 1 citations
  3. 3High <scp>CD34</scp>‐positive cell dose in matched unrelated donor allogeneic hematopoietic stem cell transplant is not associated with graft‐versus‐host disease or mortality2024 · 2 citations
  4. 4Factors associated with acute and chronic graft-versus-host disease after unrelated donor hematopoietic cell transplantation using posttransplant cyclophosphamide-based GVHD prophylaxis2025
  5. 5CD3⁺cell dose is an independent risk factor for grade II–IV aGVHD following cord blood transplantation in children with aplastic anemia2025