Factors associated with acute and chronic graft-versus-host disease after unrelated donor hematopoietic cell transplantation using posttransplant cyclophosphamide-based GVHD prophylaxis
Retrospective cohort study reveals risks of acute and chronic graft-versus-host disease after unrelated donor transplantation, highlighting graft type and donor age impacts.
Key Points
To evaluate predictors of acute and chronic graft-versus-host disease in recipients of unrelated donor hematopoietic cell transplantation with posttransplant cyclophosphamide.
Retrospective cohort study using CIBMTR dataset P5891
Included adult recipients of first unrelated donor allo-HCT from 2017 to 2021
Utilized multivariable logistic regression for data analysis
Analyzed data from 2,132 patients with a median age of 61 years
Peripheral blood stem cells and HLA mismatch linked to higher GVHD risk
Karnofsky performance score not linked to GVHD risk in multivariable models