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December 8, 2025Blood

Impact of conditioning intensity on outcomes after unrelated donor hematopoietic cell transplantation using posttransplant cyclophosphamide-based GVHD prophylaxis

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Authors

MSMoazzam ShahzadAKAmir KasaeianMHMehdi Hamadani

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Overview

Retrospective cohort analysis reveals conditioning intensity affects outcomes in unrelated donor hematopoietic cell transplant recipients, suggesting individualized approaches.

Key Points

  • This research examines how conditioning intensity impacts outcomes in unrelated donor hematopoietic cell transplantation recipients receiving posttransplant cyclophosphamide-based GVHD prophylaxis.
  • Retrospective cohort study of unrelated donor hematopoietic cell transplantation patients (2017-2021).
  • Utilized the P-598 dataset from CIBMTR for data collection.
  • Patients categorized by conditioning intensity, assessing various transplant outcomes.
  • RIC/NMA conditioning was linked to higher relapse and worse disease-free survival (DFS).
  • Grade II–IV acute GVHD rates were lower in the RIC/NMA group compared to myeloablative conditioning.
  • No significant differences were observed in overall survival, non-relapse mortality, or GVHD-free relapse-free survival.

Cite This Study

Shahzad et al. (2025) studied this question.

synapsesocial.com/papers/69362f7d4fa91c937236e50bhttps://doi.org/10.1182/blood-2025-505
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Outcomes after bone marrow versus peripheral blood mismatched unrelated donor hematopoietic cell transplantation using posttransplant cyclophosphamide-based GVHD prophylaxis2025
  2. 2Factors associated with acute and chronic graft-versus-host disease after unrelated donor hematopoietic cell transplantation using posttransplant cyclophosphamide-based GVHD prophylaxis2025
  3. 3Phase II Study of post transplant cyclophosphamide-based graft versus host disease prophylaxis after HLA-mismatched unrelated donor transplantation and reduced intensity conditioning: Results from the NMDP-sponsored access expansion Study2025
  4. 4Post-transplant cyclophosphamide based GVHD prophylaxis in HLA-matched related and unrelated donor hematopoietic cell transplantation in adults with hematologic malignancies undergoing myeloablative conditioning: A CIBMTR analysis of 8,272 participants2025
  5. 5Post-transplant cyclophosphamide (PTCy) versus other graft-versus-host disease prophylaxis strategies in reduced intensity allogeneic stem cell transplantation from related and matched unrelated donors in patients with acute myeloid leukemia and myelodysplastic syndromes: A study from the french society of bone marrow transplantation (SFGM-TC) registry2025