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December 8, 2025Blood

Outcomes after bone marrow versus peripheral blood mismatched unrelated donor hematopoietic cell transplantation using posttransplant cyclophosphamide-based GVHD prophylaxis

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Authors

MSMoazzam ShahzadMHMehdi HamadaniRBRajat Bansal

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Overview

Multicenter analysis compares graft outcomes in mismatched unrelated donor transplants, suggesting relevant clinical factors affect survival.

Key Points

  • To evaluate post-transplant outcomes associated with bone marrow and peripheral blood grafts in mismatched unrelated donor transplants using PTCy prophylaxis.
  • Retrospective multicenter analysis of adult mismatched unrelated donor allo-HCT recipients
  • Utilized P5891 dataset from the Center for International Blood and Marrow Transplant Research
  • Outcomes included overall survival, disease-free survival, and GVHD incidence
  • 559 adults underwent mismatched unrelated donor allo-HCT with PTCy-based GVHD prophylaxis
  • No significant association found between graft source and survival or GVHD outcomes
  • Age, comorbidity burden, performance status, and disease type were significant clinical factors influencing outcomes

Cite This Study

Shahzad et al. (2025) studied this question.

synapsesocial.com/papers/69362f5d4fa91c937236dca3https://doi.org/10.1182/blood-2025-934
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