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December 1, 2002Biology of Blood and Marrow TransplantationOpen Access

Risk factors for moderate-to-severe chronic graft-versus-host disease after allogeneic hematopoietic stem cell transplantation

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Authors

MRMats RembergerGKGunilla KumlienJAJ Aschan

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Overview

Cohort study reveals acute GVHD, CML, and female-to-male donation drive moderate-to-severe chronic GVHD in transplant recipients, highlighting targets for risk-adapted therapy.

Key Points

  • To identify clinical risk factors associated with the development of moderate-to-severe chronic graft-versus-host disease (cGVHD) following allogeneic hematopoietic stem cell transplantation.
  • Evaluated 679 consecutive allogeneic HSCT recipients who survived at least 3 months post-transplantation from an initial cohort of 810 patients.
  • Analyzed 30 candidate donor, recipient, and disease-related variables using multivariate hazard models across various HLA-matching categories.
  • Independent risk factors for moderate-to-severe cGVHD included grade II–IV acute GVHD (RH, 2.30; 95% CI, 1.29–4.10; P = .005), CML diagnosis (RH, 2.37; 95% CI, 1.38–4.08; P = .002), and immunized female donor to male recipient transplants (RH, 2.16; 95% CI, 1.14–4.11; P = .02).
  • The 5-year cumulative probability of moderate-to-severe cGVHD increased stepwise based on risk factor count: 5% with 0 factors, 13% with 1 factor, 23% with 2 factors, and 45% with 3 factors.
  • Among patients who developed cGVHD (n = 279), prior grade II–IV acute GVHD was the single independent predictor discriminating moderate-to-severe disease from mild disease (RH, 2.18; 95% CI, 1.23–3.86; P < .01).

Cite This Study

Remberger et al. (2002) studied this question.

synapsesocial.com/papers/6a6f5beea528af2d65c2f39bhttps://doi.org/10.1053/bbmt.2002.v8.abbmt080674
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Factors associated with acute and chronic graft-versus-host disease after unrelated donor hematopoietic cell transplantation using posttransplant cyclophosphamide-based GVHD prophylaxis2025
  2. 2Risk factors associated with chronic cutaneous graft-versus-host disease following hematopoietic stem cell transplantation: a pediatric cohort2026 · 2 citations
  3. 3Retrospective analysis of the incidence and outcome of late acute and chronic graft-versus-host disease—an analysis from transplant centers across Europe2024 · 16 citations
  4. 4Chronic graft-versus-host disease after allogeneic hematopoietic stem cell transplantation2024
  5. 5Chronic GVHD Consortium CATCH Study: Incidence, initial presentation and risk factors for chronic GVHD development2026