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March 25, 2026Anais Brasileiros de DermatologiaOpen Access

Risk factors associated with chronic cutaneous graft-versus-host disease following hematopoietic stem cell transplantation: a pediatric cohort

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Authors

DCDaniela CarvajalTDTeresa DossiCDCamila Downey

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Overview

This retrospective cohort study identifies risk factors for chronic cutaneous GVHD in children, indicating potential targets for treatment.

Key Points

  • The study aims to identify risk factors linked to chronic cutaneous graft-versus-host disease (ccGVHD) in pediatric patients following hematopoietic stem cell transplantation.
  • Retrospective cohort study design
  • Included children under 18 years who underwent HSCT from 2007 to 2017
  • Analyzed using survival and Cox regression methods
  • Follow-up period of at least 2 years
  • Examined univariate and multivariate associations with ccGVHD
  • 17.3% of participants developed ccGVHD, median onset at 8 months post-HSCT
  • Older age at transplantation, higher bone marrow graft source, related donors, and history of acute GVHD were associated with ccGVHD
  • Significant risk factors identified: male sex (HR 2.51), total body irradiation (HR 3.53), bone marrow as graft source (HR 7.28)

Cite This Study

Carvajal et al. (2026) studied this question.

synapsesocial.com/papers/69c37bc2b34aaaeb1a67e851https://doi.org/10.1016/j.abd.2026.501296
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Histopathologic Analysis of Chronic Cutaneous Graft-Versus-Host Disease2024 · 9 citations
  2. 2National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: I. Diagnosis and Staging Working Group Report2005 · 3,578 citations
  3. 3Graft-Versus-Host Disease in Children Who Have Received a Cord-Blood or Bone Marrow Transplant from an HLA-Identical Sibling2000 · 871 citations
  4. 4Hematopoietic Stem Cell Transplantation in Children and Adolescents2016 · 19 citations