What question did this study set out to answer?

This review aims to investigate the risk factors contributing to the rising incidence of pediatric cancers in the United States.

December 8, 2025Blood

Pediatric cancer risk factors: A review of literature

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Literature review identifies significant risk factors linked to pediatric cancer incidence in childhood, indicating critical areas for prevention.

This review aims to investigate the risk factors contributing to the rising incidence of pediatric cancers in the United States.
Conducted a systematic literature review of 3,862 studies published between January 2014 and March 2021.
Reviewed studies on childhood, pregnancy and birth-related, and environmental risk factors for pediatric cancers.
Utilized Ovid MEDLINE and Scopus databases for comprehensive search criteria.
Identified significant associations between various risk factors and increasing pediatric cancer incidence.
Confirmed risk factors include genetic predisposition, birth defects, and medical ionizing radiation.
Documented maternal and environmental exposures linked to increased cancer risk, such as pesticides and prenatal factors.

Ricci et al. (2025) studied this question.

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Literature review identifies significant risk factors linked to pediatric cancer incidence in childhood, indicating critical areas for prevention.