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December 8, 2025BloodOpen Access

High protein expression of MDS1 and EVI1 complex locus (MECOM) is prognostically adverse and independent of chromosome 3 rearrangements in acute myelogenous leukemia

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Authors

SKSteven M. KornblauBBBrandon BrownYQYihua Qiu

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Overview

High EVI1 levels indicate poor outcomes in acute myelogenous leukemia, suggesting new targets for therapy.

Key Points

  • To evaluate the impact of EVI1 protein levels on the prognosis of acute myelogenous leukemia (AML).
  • Measured protein levels in 806 newly diagnosed AML patient samples using Reverse Phase Protein Arrays.
  • Compared EVI1 expression in relation to chromosome 3 alterations and clinical outcomes.
  • Analyzed data using Cox proportional hazards models for survival analysis.
  • High EVI1 expression linked to poor overall survival in AML cases.
  • EVI1 levels stratified patients into distinct prognostic groups.
  • Proteomic analysis revealed shared expression profiles despite different EVI1 isoforms.

Cite This Study

Kornblau et al. (2025) studied this question.

synapsesocial.com/papers/69362f6c4fa91c937236e04chttps://doi.org/10.1182/blood-2025-5258
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