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December 8, 2025Blood

Impact of MGUS on comorbidities and outcomes in patients with multiple myeloma: A propensity-matched analysis

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To analyze the impact of MGUS on comorbidities and outcomes in patients with multiple myeloma.
Conducted propensity score matching analysis on multiple myeloma patients
Assessed the impact of MGUS on osteoporosis and comorbidities
Used logistic regression to evaluate associations adjusting for demographic factors
MGUS associated with higher odds of iron deficiency anemia (OR = 2.20, p < 0.001)
Increased odds of chronic kidney disease in MGUS patients (OR = 1.25, p = 0.028)
No significant association found for osteoporosis or in-hospital mortality

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Propensity score matching shows MGUS increases risk of iron deficiency anemia and chronic kidney disease.

Zengin et al. (2025) studied this question.

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