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December 8, 2025Blood

Early intervention in smoldering multiple myeloma: A systematic review of comparative prospective trials

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Authors

TNTaiga Nishihori

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Overview

Systematic review shows early intervention improves progression-free survival in intermediate/high-risk smoldering multiple myeloma, indicating potential benefits of treatment strategies.

Key Points

  • This review evaluates the outcomes of comparative prospective studies on early treatment strategies for smoldering multiple myeloma.
  • Conducted a systematic review adhering to PRISMA guidelines.
  • Searched Medline, Embase, Cochrane, and ClinicalTrials.gov for relevant studies.
  • Included prospective studies comparing treatment strategies in intermediate/high-risk smoldering multiple myeloma.
  • 182 patients included across five eligible studies.
  • Four studies were randomized controlled trials.
  • Comparative trials suggested significant improvements in progression-free survival with early treatment options.

Cite This Study

Taiga Nishihori (2025) studied this question.

synapsesocial.com/papers/69362f6e4fa91c937236e088https://doi.org/10.1182/blood-2025-7575
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Early therapeutic intervention versus observation in high-risk smoldering multiple myeloma: A systematic review and meta-analysis.2026
  2. 2Smoldering Multiple Myeloma: Early Intervention or Structured Surveillance? A Comprehensive Review of Evidence for and Against Early Therapy2026
  3. 3High-Risk Smoldering Multiple Myeloma: A Review of Controversies in Early Treatment Versus Observation2026
  4. 4High-risk smoldering myeloma – a case for early intervention?2025
  5. 5Smoldering Multiple Myeloma: From Clinical to Immunogenomic Risk Stratification and Therapeutic Implications of Early Intervention2026