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December 8, 2025Blood

Increased FXII activation in endovascular treated stroke patients on periprocedural antithrombotic treatment

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Authors

ACAngelique CeulemansBRBob RoozenbeekHSHenri M.H. Spronk

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Overview

Observational study links increased FXII activation with hemorrhages in stroke, suggesting a need for safer antithrombotics.

Key Points

  • To investigate the relationship between FXII activation and clinical outcomes in acute ischemic stroke patients undergoing endovascular treatment.
  • Analyzed plasma biomarkers from patients in the MR CLEAN MED Trial at three time points post-EVT.
  • Measured coagulation activity including activated factor XII and NETs markers using ELISA.
  • Assessed correlations and differences using Pearson correlation and multivariable regression analysis.
  • FXII activation increased after antithrombotic treatment, but did not correlate with clinical outcomes.
  • Intracranial hemorrhage rates were higher with UFH and ASA treatments.
  • Neutrophil extracellular traps showed variability in correlation with coagulation factors.

Cite This Study

Ceulemans et al. (2025) studied this question.

synapsesocial.com/papers/69362f6e4fa91c937236e16bhttps://doi.org/10.1182/blood-2025-1358
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Multicenter randomized clinical trial of endovascular treatment for acute ischemic stroke. The effect of periprocedural medication: acetylsalicylic acid, unfractionated heparin, both, or neither (MR CLEAN-MED). Rationale and study design2020 · 35 citations
  2. 2Abstract WP055: Safety and Efficacy of Periprocedural Antithrombotics in Endovascular Stroke Treatment: A Systematic Review and Network Meta-Analysis2026
  3. 3ABSTRACT NUMBER: ESOC2026A2290 INTRA-ARTERIAL THROMBOLYTICS AFTER ENDOVASCULAR THROMBECTOMY FOR ACUTE ISCHEMIC STROKE: A NETWORK META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS2026
  4. 4Acute ischemic stroke and reperfusion drive molecular immune-vascular activations detectable in peripheral blood2025 · 5 citations
  5. 5Abstract 403: Antiplatelet therapy for patients undergoing mechanical thrombectomy for acute ischemic stroke: a review2025