Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 8, 2025Blood

Oxidative stress and hemoglobin-c denaturation drive hemoglobin SC pathophysiology and can be ameliorated by antioxidants and hydroxyurea

View Full Paper
Ask AI
Bookmark
Share

Authors

ATAnifat TijaniCincinnati Children's Hospital Medical CenterRWRussell E. WareCincinnati Children's Hospital Medical CenterPMPunam MalikCincinnati Children's Hospital Medical Center

Discussion

Loading...

Member takes

Implication

Randomized trial shows hydroxyurea reduces pain in HbSC patients, indicating oxidative stress is a key factor.

Key Points

  • To investigate the role of oxidative stress in hemoglobin SC disease and the effects of hydroxyurea and antioxidants.
  • Conducted a randomized trial of hydroxyurea in HbSC disease patients.
  • Developed a murine model of HbSC disease using CRISPR-Cas9.
  • Assessed RBC deformability, sickling kinetics, and oxidative stress via multiple ektacytometry techniques.
  • Hydroxyurea significantly reduced vaso-occlusive pain events in HbSC patients.
  • Quercetin supplementation lowered Heinz body formation and improved RBC membrane deformability in mice.
  • Higher oxidative stress levels were observed in HbSC RBC compared to HbCC and HbSS RBC.

Cite This Study

Tijani et al. (2025) studied this question.

synapsesocial.com/papers/69362f714fa91c937236e183https://doi.org/10.1182/blood-2025-7
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1PO85 | Acute retinal ischemia in hemoglobin SC disease: a case report and review of the literature2025
  2. 2The Protective Effect of Fetal Hemoglobin on Retinal Damage in Sickle Cell Disease Patients: A Correlation With Optical Coherence Tomography, Hematologic Parameters, and Hydroxyurea Treatment2025 · 3 citations
  3. 3Mean corpuscular hemoglobin modulates HbF distribution and sub-phenotypes of sickle cell disease2025
  4. 4Hemoglobin SC disease: Clinical analysis from the Georgia comprehensive sickle cell center at grady memorial hospital, Atlanta, Georgia.2025
  5. 5Sickling kinetics drive genotype-specific impairment of RBC deformability in sickle cell disease2025