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This research aims to assess the neurotoxic effects of perfluorooctanoic acid on male Wistar rats through various biological markers.

Impact of Redox Imbalance and Mitochondrial Dysfunction on Neurotoxicity Induced by Perfluorooctanoic Acid in Male Wistar Albino Rats ( Rattus norvegicus )

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Animal study reveals oxidative stress and mitochondrial dysfunction from PFOA exposure, indicating neurotoxicity risks.

This research aims to assess the neurotoxic effects of perfluorooctanoic acid on male Wistar rats through various biological markers.
The study administered oral doses of PFOA (48 mg/kg and 96 mg/kg) for 30, 60, and 90 days.
Neurotoxicity was assessed via oxidative stress markers and mitochondrial function in brain samples.
Histological and immunohistochemical techniques were used to evaluate brain tissue changes.
PFOA exposure elevated oxidative stress levels and lipid peroxidation.
Mitochondrial dysfunction was confirmed by a disrupted membrane potential.
Neuronal degeneration and reactive gliosis were observed in the histological analysis.

Hongal et al. (2025) studied this question.

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