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This research aims to evaluate the clinical outcomes and immunological characteristics of EBV infection in T cells following allo-HSCT.

December 8, 2025Blood

Ectopic EBV infection in T cells following allogeneic hematopoietic stem cell transplantation: Clinical outcomes and immunological characterization

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This research aims to evaluate the clinical outcomes and immunological characteristics of EBV infection in T cells following allo-HSCT.
147 allo-HSCT patients with EBV infection were enrolled.
Patients were grouped into T-cell infection and non-T-cell infection groups.
Flow cytometry was used to isolate lymphocyte subsets and assess EBV DNA levels.
Patients were compared across various clinical parameters to analyze outcomes.
Multivariate Cox regression was utilized to identify risk factors for T-cell infection.
62.6% of patients developed post-transplant lymphoproliferative disorder (PTLD).
The T-cell infection group had a significantly higher PTLD incidence (69.5% vs. 45.2%).
No significant differences were found in overall survival or non-relapse mortality between groups.
T-cell infection was associated with impaired IFN-γ production, indicating T-cell exhaustion.

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Clinical outcomes reveal increased PTLD risk and immune reconstitution impairment in T-cell infected patients after HSCT, highlighting EBV's role.

Lan‐Ping Xu (2025) studied this question.

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Clinical outcomes reveal increased PTLD risk and immune reconstitution impairment in T-cell infected patients after HSCT, highlighting EBV's role.