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December 8, 2025BloodOpen Access

Preliminary efficacy and safety of the Bruton tyrosine kinase degrader BGB-16673 in patients with relapsed/refractory Richter transformation: Results from the ongoing phase 1 CaDAnCe-101 study

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Authors

MTMeghan C. ThompsonMDMartin DreylingIAInhye E. Ahn

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Overview

Ongoing phase 1 trial shows BGB-16673 improves overall response in patients with relapsed Richter transformation, suggesting its potential for treatment.

Key Points

  • This study evaluates the efficacy and safety of BGB-16673 in patients with relapsed/refractory Richter transformation.
  • Open-label phase 1 trial
  • Patients had prior treatments for chronic lymphocytic leukemia or Richter transformation
  • BGB-16673 administered orally in 28-day cycles
  • Primary objectives included assessing safety and tolerability, establishing maximum tolerated dose
  • 52.4% overall response rate observed in evaluable patients
  • Common treatment-emergent adverse events included neutropenia (37.5%) and anemia (12.5%)
  • Maximum tolerated dose was assessed as part of safety objectives

Cite This Study

Thompson et al. (2025) studied this question.

synapsesocial.com/papers/69362f714fa91c937236e20ehttps://doi.org/10.1182/blood-2025-3895
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Updated efficacy and safety results of the Bruton tyrosine kinase degrader BGB-16673 in patients with relapsed/refractory indolent non-Hodgkin lymphoma from the ongoing phase 1 CaDAnCe-101 study2025
  2. 2CaDAnCe-304, a phase 3, open-label, randomized study to evaluate the safety and efficacy of Bruton tyrosine kinase degrader BGB-16673 compared with pirtobrutinib in patients with relapsed/refractory chronic lymphocytic leukemia/small lymphocytic lymphoma2025 · 1 citations
  3. 3CaDAnCe-104, an ongoing, open-label, phase 1b/2 master protocol study of Bruton tyrosine kinase degrader BGB-16673 in combination with other agents in patients with relapsed/refractory B-cell malignancies2025 · 3 citations
  4. 4Updated efficacy and safety results of the Bruton tyrosine kinase degrader BGB-16673 in patients with relapsed/refractory Waldenström macroglobulinemia from the ongoing phase 1 CaDAnCe-101 study2025 · 4 citations
  5. 5CaDAnCe-302, a phase 3, open-label, randomized study of BGB-16673 compared with idelalisib + rituximab (R), bendamustine + R, or venetoclax + R re-treatment in patients with chronic lymphocytic leukemia/small lymphocytic lymphoma previously exposed to both a BTK and BCL2 inhibitor2025