What question did this study set out to answer?

To evaluate the pattern of infections and the impact on immunocompetence in NHL patients following B-cell depleting immunotherapies.

December 8, 2025BloodOpen Access

Pattern of infections and impact on immunocompetence of next generation B-cell depleting immunotherapies in non-Hodgkin's lymphomas: Results from a multicentre retrospective real- life cohort.

View Full Paper

Ask AI

Bookmark

Authors

ACAlessia CastellinoAzienda Sanitaria Ospedaliera S.Croce e Carle Cuneo LNLuigi NigriEuropean Federation of Animal Science MBMatteo BisioAzienda Ospedaliera Citta' della Salute e della Scienza di Torino

Discussion

Member takes

Implication

Multicenter study finds high infection rates in NHL patients receiving B-cell depleting immunotherapies, indicating severe immunocompetence challenges.

Key Points

To evaluate the pattern of infections and the impact on immunocompetence in NHL patients following B-cell depleting immunotherapies.
Conducted a multicenter retrospective study
Included NHL patients treated with novel immunotherapies
Evaluated infection incidence, type, and outcomes
Observed 112 infective events in 110 patients
Most infections occurred within the first 100 days of treatment
Bacterial infections were more common than viral infections
Treatment in Mantle cell and Follicular lymphomas associated with higher infection risk
55 deaths reported, primarily due to lymphoma progression

Cite This Study

Castellino et al. (2025) studied this question.

synapsesocial.com/papers/69362f744fa91c937236e260 https://doi.org/10.1182/blood-2025-5499

View Full Paper

Ask AI

Bookmark

Implication

Multicenter study finds high infection rates in NHL patients receiving B-cell depleting immunotherapies, indicating severe immunocompetence challenges.

Pattern of infections and impact on immunocompetence of next generation B-cell depleting immunotherapies in non-Hodgkin's lymphomas: Results from a multicentre retrospective real- life cohort.

Discussion

Member takes

Implication

Key Points

Cite This Study

Pattern of infections and impact on immunocompetence of next generation B-cell depleting immunotherapies in non-Hodgkin's lymphomas: Results from a multicentre retrospective real- life cohort.

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider