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December 8, 2025BloodOpen Access

Rapidly progressive acute chest syndrome is associated with complement-mediated cell injury in adults with sickle cell disease

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Authors

JFJ.L. FigueroaRBRobert A. BrodskyMCMichael D. Cole

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Overview

Study finds complement activation in sickle cell disease patients with rapidly progressive acute chest syndrome, suggesting implications for treatment with eculizumab.

Key Points

  • To investigate the relationship between rapidly progressive acute chest syndrome and complement activation in adults with sickle cell disease.
  • Adults with SCD were enrolled into three groups: RP-ACS, ACS without respiratory failure, and SCD controls without ACS.
  • Blood samples were collected for assessment of complement-mediated cell injury using the mHam assay and flow cytometry.
  • Statistical comparisons between groups used Fisher's exact test and Mann-Whitney test.
  • 100% of RP-ACS patients had positive mHam assays, compared to 0% in ACS and no-ACS groups (p = 0.005).
  • Mean percentage of nonviable cells was significantly higher in RP-ACS group (43.4%) than in ACS (8.2%) and no-ACS (7.7%).
  • Both RP-ACS patients died within a mean of 2 days.

Cite This Study

Figueroa et al. (2025) studied this question.

synapsesocial.com/papers/69362f744fa91c937236e2c2https://doi.org/10.1182/blood-2025-6485
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Deep neutrophil phenotyping uncovers complement-mediated neutrophil dysregulation in sickle cell disease2025
  2. 2Complement dysregulation during vaso-occlusive episodes can predict development of acute chest syndrome in pediatric patients with sickle cell disease2025
  3. 3C65-12 Clinical and Laboratory Findings in Adults With Sickle Cell Disease Which Increase Risk for Severe Acute Chest Syndrome2026
  4. 4Clinical and laboratory findings in adults with sickle cell disease which increase risk for severe acute chest syndrome2025
  5. 5B52-42 Not Just Another Crisis Severe Atypical Acute Chest Syndrome2026