Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 8, 2025BloodOpen Access

Allograft for myeloid malignancies in the year of 70 years old and beyond: No impact of pre-graft immune, nutritional and inflammatory status on outcome.

View Full Paper
Ask AI
Bookmark
Share

Authors

ADAmbre DeniniolleSVSophie VantyghemAFAude-Marie Fourmont

Discussion

Loading...

Member takes

Overview

Retrospective study shows no effect of immune and nutritional status on survival in elderly patients undergoing allogeneic stem cell transplantation.

Key Points

  • This research aims to assess the influence of pre-graft nutritional, immune, and inflammatory status on outcomes of allogenic stem cell transplantation in elderly patients.
  • Conducted as a retrospective monocentric study
  • Evaluated 58 patients aged 70 years and older after allograft
  • Analyzed overall survival, progression free survival, and non-relapse mortality
  • Considered immune markers, nutritional status (albumin), and inflammatory markers (ferritin, CRP, fibrinogen)
  • 2-year overall survival was 64%, with 5-year survival at 47%
  • Nutritional status showed high levels of ferritin and few cases of hypoalbuminemia
  • None of the immune or inflammatory markers significantly impacted survival outcomes
  • AML showed better outcomes compared to other myeloid malignancies

Cite This Study

Deniniolle et al. (2025) studied this question.

synapsesocial.com/papers/69362f744fa91c937236e2dchttps://doi.org/10.1182/blood-2025-7785
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prognostic Value of Geriatric Characteristics in Allogeneic Haematopoietic Stem Cell Transplant Recipients Aged Over 60 Years2025
  2. 2Allogeneic Hematopoietic Stem Cell Transplantation for Older Patients with Hematological Malignancies2025 · 1 citations
  3. 3Comparable outcomes in patients aged ≥70 vs. <70 undergoing allogeneic transplantation with fludarabine and melphalan conditioning and post-transplant cyclophosphamide2025
  4. 4Outcomes of older adults undergoing allogeneic stem cell transplant with post-transplant cyclophosphamide.2024
  5. 5Improvements in Posttransplant Outcomes Over Two Decades in Older Patients with Acute Myeloid Leukemia in the EBMT ALWP Study2024 · 25 citations