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December 8, 2025BloodOpen Access

Real-world zanubrutinib treatment patterns in CLL/SLL among a curated sample of US community oncology patients with prior acalabrutinib therapy

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Authors

RCRushir J. ChoksiXWXiaogang WangBCBeverly Chigarira

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Overview

Retrospective cohort assessed treatment patterns and discontinuation reasons for CLL patients after switching from acalabrutinib to zanubrutinib, highlighting toxicity as a primary reason.

Key Points

  • This research aims to investigate treatment patterns and reasons for discontinuation in CLL patients who switched from acalabrutinib to zanubrutinib.
  • Used the IntegraConnect PrecisionQ database for a retrospective cohort study
  • Identified CLL/SLL patients who changed therapies
  • Conducted medical record review to assess treatment initiation, discontinuation, and reasons
  • 806 patients initiated acalabrutinib, with 121 switching to zanubrutinib
  • 72.5% of patients received acalabrutinib in first-line treatment
  • Key reasons for acalabrutinib discontinuation included toxicity (68.6%) and disease progression (6.9%)

Cite This Study

Choksi et al. (2025) studied this question.

synapsesocial.com/papers/69362f744fa91c937236e2ffhttps://doi.org/10.1182/blood-2025-8041
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