What type of study is this?

This is a Pre-Registered Trial study.

What question did this study set out to answer?

To evaluate the efficacy and safety of radiation-free therapy in patients with early-stage Hodgkin Lymphoma.

December 8, 2025Blood

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Phase II trial finds radiation-free therapy may improve outcomes in early Hodgkin Lymphoma patients, suggesting further investigation is warranted.

To evaluate the efficacy and safety of radiation-free therapy in patients with early-stage Hodgkin Lymphoma.
Phase II, multicenter, prospective trial
Included untreated, stage I–IIA Hodgkin Lymphoma patients aged 18–70
Used interim PET results and metabolic tumor volume to stratify patients
About 70% of patients achieved a negative interim PET after chemotherapy
Primary endpoint is 3-year progression-free survival, aiming for a rate of 90% in low-risk patients
Circulating tumor DNA monitored every 3 months for high-risk patients

Picardi et al. (2025) studied this question.

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Phase II trial finds radiation-free therapy may improve outcomes in early Hodgkin Lymphoma patients, suggesting further investigation is warranted.