What type of study is this?

This is a Human Clinical Trial study (also classified as: Phase 2, Phase 3).

What question did this study set out to answer?

This trial aims to assess the effectiveness of early versus on-demand palliative care referrals in patients with high-risk leukemias and myelodysplastic syndrome.

December 8, 2025Blood

Early and sustained palliative care intervention is not superior to on-demand palliative care referral for patients with high-risk leukemias or myelodysplastic syndrome

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Authors

LBLeslie BlackhallUniversity of Virginia Health System KBKaren K. BallenUniversity of Virginia Health System

Discussion

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Implication

Randomized trial shows no difference in ICU deaths or overall survival for patients with hematologic malignancies receiving palliative care.

Key Points

This trial aims to assess the effectiveness of early versus on-demand palliative care referrals in patients with high-risk leukemias and myelodysplastic syndrome.
Conducted as a Phase II randomized trial at an academic medical center.
Included participants aged ≥65 with newly diagnosed AML, ALL, CMML, or high-risk MDS and adults with relapsed/refractory disease.
Randomized 3:2 to assess early palliative care versus standard of care with outcomes focused on place of death and quality of life.
78% of participants experienced death before the trial ended, with similar ICU death rates in both groups.
One-year overall survival was statistically similar between early palliative care and standard care.
Hospice utilization was lower in the early PC arm, but not statistically significant.

Cite This Study

Blackhall et al. (2025) studied this question.

synapsesocial.com/papers/69362f764fa91c937236e35a https://doi.org/10.1182/blood-2025-961

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Implication

Randomized trial shows no difference in ICU deaths or overall survival for patients with hematologic malignancies receiving palliative care.

Early and sustained palliative care intervention is not superior to on-demand palliative care referral for patients with high-risk leukemias or myelodysplastic syndrome

Discussion

Member takes

Implication

Key Points

Cite This Study

Early and sustained palliative care intervention is not superior to on-demand palliative care referral for patients with high-risk leukemias or myelodysplastic syndrome

Discussion

Member takes

Implication

Key Points

Cite This Study

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