What type of study is this?

This is a Human Clinical Trial study (also classified as: RCT).

What question did this study set out to answer?

To compare two different schedules of high-dose cytarabine administration in AML patients achieving complete remission.

December 8, 2025BloodOpen Access

Comparison of consecutive versus alternate day schedules of high-dose cytarabine consolidation chemotherapy in Acute Myeloid Leukemia: Single-center randomized controlled trial from India

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Authors

PSParas SatadeveAll India Institute of Medical Sciences Rishikesh MKMayank KapoorAll India Institute of Medical Sciences Rishikesh

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Implication

Randomized controlled trial shows reduced hospitalization and improved tolerability in AML patients receiving consecutive high-dose cytarabine treatment.

Key Points

To compare two different schedules of high-dose cytarabine administration in AML patients achieving complete remission.
Randomized controlled trial involving AML patients in India
Compared consecutive (HiDAC-123) vs alternate day (HiDAC-135) high-dose cytarabine schedules
Monitored neutropenia, thrombocytopenia, and other adverse events during treatment
HiDAC-123 group showed faster neutrophil recovery (13.87 days) vs HiDAC-135 (17.46 days)
Median hospitalization duration was shorter in HiDAC-123 group (14.52 days) than HiDAC-135 (18.5 days)
G-CSF doses required were significantly lower in HiDAC-123 group (9.32 doses) compared to HiDAC-135 (18.5 doses)

Cite This Study

Satadeve et al. (2025) studied this question.

synapsesocial.com/papers/69362f764fa91c937236e3ce https://doi.org/10.1182/blood-2025-1687

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Implication

Randomized controlled trial shows reduced hospitalization and improved tolerability in AML patients receiving consecutive high-dose cytarabine treatment.

Comparison of consecutive versus alternate day schedules of high-dose cytarabine consolidation chemotherapy in Acute Myeloid Leukemia: Single-center randomized controlled trial from India

Discussion

Member takes

Implication

Key Points

Cite This Study

Comparison of consecutive versus alternate day schedules of high-dose cytarabine consolidation chemotherapy in Acute Myeloid Leukemia: Single-center randomized controlled trial from India

Discussion

Member takes

Implication

Key Points

Cite This Study

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