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December 8, 2025BloodOpen Access

The synonymous IDH1 p.Gly105Gly (rs11554137) variant associates with AML post-transplant relapse via aberrant signal transduction pathways

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Authors

MSMithun Vinod ShahMayo ClinicDCDong ChenNanjing University of Chinese MedicineJFJames M. ForanJacksonville College

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Implication

Observational study shows IDH1 Gly105Gly variant predicts post-SCT relapse in AML, suggesting implications for treatment intensity.

Key Points

  • To assess the prognostic significance of the IDH1 Gly105Gly variant in AML post-allogeneic stem cell transplantation.
  • Clinical and genomic data extraction from Mayo Clinic AML database
  • Patient stratification by IDH1 Gly105Gly status using NGS
  • Outcomes measured included treatment response, MRD, and survival analysis using Cox regression models.
  • 9.5% of AML patients harbored the IDH1 Gly105Gly variant
  • Higher complete remission rates with intensive therapy (70%) compared to low-intensity (17%)
  • IDH1 Gly105Gly was independently associated with shorter relapse-free survival (HR 3.97)

Cite This Study

Shah et al. (2025) studied this question.

synapsesocial.com/papers/69362f764fa91c937236e3d8https://doi.org/10.1182/blood-2025-1699
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1IDH2 R172 mutation is associated with improved survival in IDH-mutated AML/MDS patients undergoing allogeneic stem cell transplantation: A geth-TC multicenter study2025
  2. 2Isocitrate Dehydrogenase (IDH) 1 and 2 Mutations Predicts Better Outcome in Patients with Acute Myeloid Leukemia Undergoing Allogeneic Hematopoietic Cell Transplantation: a study of the ALWP of the EBMT2024
  3. 3The association of IDH co-mutations with treatment outcomes and overall survival in TP53 -mutated acute myeloid leukemia.2026
  4. 4Prevalence and Prognostic Role of IDH Mutations in Acute Myeloid Leukemia: Results of the GIMEMA AML1516 Protocol2022 · 20 citations
  5. 5IDH mutant MDS: Proposal for disease subset recognition based on molecular and clinical features, and the availability of targeted therapies2025