What question did this study set out to answer?

To evaluate outcomes of CD20-directed bispecific antibodies and CD19-directed CAR T therapy in patients with R/R large B cell lymphoma after prior T cell therapy.

December 8, 2025BloodOpen Access

Sequencing CD20-directed bispecific antibody and CD19-directed CAR T cell therapy in large B cell lymphoma: A multicenter real-world study

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To evaluate outcomes of CD20-directed bispecific antibodies and CD19-directed CAR T therapy in patients with R/R large B cell lymphoma after prior T cell therapy.
Retrospective study across 9 centers (CUBIC consortium)
Patients received either CAR T before BsAb or BsAb before CAR T
Outcomes measured included progression-free survival, complete response rate, overall response rate, and overall survival
Best overall response rate to prior CAR T was 70%, with a complete response rate of 39%
Median progression-free survival was 3.6 months after BsAb
Cytokine release syndrome occurred in 35% of patients after BsAb

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Implication

Multicenter study evaluates progression-free survival in relapsed large B cell lymphoma with bispecific antibodies and CAR T cell therapy, indicating treatment sequencing impacts efficacy.

Cite This Study

Qualls et al. (2025) studied this question.

synapsesocial.com/papers/69362f764fa91c937236e405 https://doi.org/10.1182/blood-2025-3663

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Implication

Multicenter study evaluates progression-free survival in relapsed large B cell lymphoma with bispecific antibodies and CAR T cell therapy, indicating treatment sequencing impacts efficacy.

Sequencing CD20-directed bispecific antibody and CD19-directed CAR T cell therapy in large B cell lymphoma: A multicenter real-world study

Key Points

Discussion

Implication

Cite This Study

Sequencing CD20-directed bispecific antibody and CD19-directed CAR T cell therapy in large B cell lymphoma: A multicenter real-world study

Key Points

Discussion

Implication

Cite This Study

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