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December 8, 2025Blood

Reattempt of tyrosine kinase inhibitor discontinuation after maintenance therapy with ponatinib in patients with chronic myeloid leukemia in the chronic phase: Result of JALSG CML RE-STOP219 study.

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Authors

MSMasuho SaburiNANobuyuki AotsukaHYHiroki Yokoyama

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Overview

Single-arm trial finds 36.6% TFR at 12 months post-ponatinib therapy in chronic myeloid leukemia patients, indicating potential benefits over TKI resumption.

Key Points

  • Evaluate the possibility of achieving treatment-free remission after maintenance therapy with ponatinib in chronic myeloid leukemia patients.
  • Single-arm, open-label trial
  • 49 patients received ponatinib after TKI discontinuation
  • Followed for 12 months with observation for treatment-free remission
  • TFR rate at 12 months was 36.6%
  • Majority of patients (73.2%) were male with median age of 46
  • Adverse events reported in 6.1% of cases including cardiovascular complications

Cite This Study

Saburi et al. (2025) studied this question.

synapsesocial.com/papers/69362f764fa91c937236e41ahttps://doi.org/10.1182/blood-2025-5546
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Reattempt of tyrosine kinase inhibitor discontinuation after maintenance therapy with ponatinib in patients with chronic myeloid leukaemia in the chronic phase: Result of the <scp>Japan Adult Leukemia Study Group RE</scp> ‐ <scp>STOP219</scp> study2026 · 1 citations
  2. 2Predictors of successful tirosine kinase inhibitor discontinuation in chronic myeloid leukemia: Long-term, real-world evidence on the role of faster molecular decline and duration of response2025
  3. 3Treatment-free remission in patients with chronic myeloid leukemia following the second discontinuation of tyrosine kinase inhibitors2025
  4. 4Five-year interim analysis of multi-institutional collaborative study for estimating the persistence of treatment free remission in chronic myeloid leukemia after stopping tyrosine kinase inhibitor in Japan: J-SKI2025 · 1 citations
  5. 5Second attempt to discontinue TKI after molecular relapse in patients with chronic myeloid leukemia: A real‐life Italian multicenter study2026