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December 8, 2025Blood

Cost analysis compared with efficacy shows iron dextran surpassing other intravenous iron formulations in children: A tertiary children's hospital experience

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Authors

KRKaleigh Riggs‐HarpurThe University of Texas Health Science Center at HoustonNMNeethu MenonMemorial Hermann

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Overview

Retrospective review finds iron dextran most effective for improving hemoglobin and ferritin in children, suggesting better cost-effectiveness.

Key Points

  • To compare the cost and efficacy of various intravenous iron formulations in treating iron deficiency in children.
  • Conducted a retrospective chart review of IVI therapy in subjects aged ≤21 years.
  • Collected data on demographics, IVI formulations, dosage, hemoglobin, and ferritin levels pre- and post-treatment.
  • Used Kruskal Wallis test for efficacy comparison and linear mixed model for cost analysis.
  • Administered 833 doses; median improvement in hemoglobin was 1.2 g/dL, highest with iron dextran at 1.9 g/dL.
  • Iron dextran showed the greatest improvement in ferritin levels compared to other formulations.
  • Median cost per treatment was lowest for iron sucrose and highest for ferric carboxymaltose.

Cite This Study

Riggs‐Harpur et al. (2025) studied this question.

synapsesocial.com/papers/69362f7d4fa91c937236e441https://doi.org/10.1182/blood-2025-6174
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Safety and efficacy analysis of IV iron formulations in children: Results from a large pediatric cohort2025
  2. 2Pediatric Intravenous Iron Therapy: Evaluating the Safety and Efficacy of Iron Isomaltoside and Low‐Molecular‐Weight Dextran2025 · 1 citations
  3. 3Treatment targeting pediatric inflammatory bowel disease-associated anemia: experience from a single tertiary center2025
  4. 4Iron Therapy in Pediatric Iron Deficiency and Iron-Deficiency Anemia: Efficacy, Safety, and Formulation-Specific Trade-Offs—A Narrative Review2026 · 2 citations
  5. 5A Cost-utility Analysis of Ferric Derisomaltose versus Ferric Carboxymaltose in Patients with Iron Deficiency Anemia in China2024