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December 8, 2025Blood

Safety and efficacy analysis of IV iron formulations in children: Results from a large pediatric cohort

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Authors

SCSamanta CatuenoLSLakshmi Srivaths

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Overview

Retrospective chart review demonstrates improved hemoglobin and ferritin levels in children with iron deficiency, implying safety of IV iron formulations.

Key Points

  • To compare the clinical efficacy and adverse effects of various intravenous iron formulations in children.
  • Retrospective chart review of patients ≤21 years receiving IV iron from 2018-2024
  • Analysis of demographics, indications, hemoglobin, ferritin, phosphorous, and adverse reactions
  • Statistical analyses included Wilcoxon signed-rank, Kruskal-Wallis, and logistic mixed models
  • 344 patients received a total of 661 IV iron treatments
  • Median hemoglobin improved from 9.1 g/dL to 10.9 g/dL
  • Median ferritin improved from 6 ng/ml to 39 ng/ml across all formulations
  • Adverse reactions occurred in 5.6% of doses, with 4 anaphylactic reactions
  • Hypophosphatemia was noted in 45% of treatments with available phosphorus levels

Cite This Study

Catueno et al. (2025) studied this question.

synapsesocial.com/papers/69362f634fa91c937236ddc7https://doi.org/10.1182/blood-2025-2906
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Also Consider

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  1. 1Cost analysis compared with efficacy shows iron dextran surpassing other intravenous iron formulations in children: A tertiary children's hospital experience2025
  2. 2Pediatric Intravenous Iron Therapy: Evaluating the Safety and Efficacy of Iron Isomaltoside and Low‐Molecular‐Weight Dextran2025 · 1 citations
  3. 3Treatment targeting pediatric inflammatory bowel disease-associated anemia: experience from a single tertiary center2025
  4. 4Iron Therapy in Pediatric Iron Deficiency and Iron-Deficiency Anemia: Efficacy, Safety, and Formulation-Specific Trade-Offs—A Narrative Review2026 · 2 citations
  5. 5Adherence to oral iron in adolescent females with iron deficiency secondary to heavy menstrual bleeding2025