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December 8, 2025BloodOpen Access

Targeting hemolysis and raas: Osivelotor and losartan ameliorate sickle cell renal pathology

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Authors

SSSuman SettyGRGuohui RenZIZalaya K. Ivy

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Overview

Experiments demonstrate that osivelotor and losartan enhance kidney function in sickle cell models, suggesting dual-targeting is beneficial.

Key Points

  • This research aims to determine the effects of osivelotor and losartan on kidney health in sickle cell disease.
  • Transgenic sickle mice were treated with osivelotor, losartan, or both for 14 weeks.
  • Markers of hemolysis, oxidative stress, kidney injury, and function were measured.
  • Histopathology was assessed to determine structural kidney changes.
  • Osivelotor treatment elevated hemoglobin concentrations and improved hemolytic biomarkers compared to controls.
  • Kidney function demonstrated a significant reduction in albuminuria with both treatments.
  • Histopathological assessments showed reduced severity of kidney damage with the combination treatment.

Cite This Study

Setty et al. (2025) studied this question.

synapsesocial.com/papers/69362f7d4fa91c937236e47ahttps://doi.org/10.1182/blood-2025-1147
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