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Evaluate the utility of RBC transfusions in patients hospitalized for vaso-occlusive episodes in sickle cell disease.

December 8, 2025BloodOpen Access

Examining the utility of RBC transfusions in uncomplicated vaso-occlusive episodes

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Retrospective cohort study demonstrated RBC transfusions reduced pain scores in patients with vaso-occlusive episodes, implying effects on treatment.

Evaluate the utility of RBC transfusions in patients hospitalized for vaso-occlusive episodes in sickle cell disease.
Conducted a retrospective cohort study
Involved adults 21 years and older hospitalized for VOE
Evaluated changes in pain scores, opioid usage, and other clinical outcomes
RBC transfusions reduced pain scores by 2.5 units at 24 hours
No significant difference in opioid usage before and after transfusion
Transfused patients had longer lengths of stay in hospital

Nguyen et al. (2025) studied this question.

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Retrospective cohort study demonstrated RBC transfusions reduced pain scores in patients with vaso-occlusive episodes, implying effects on treatment.