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December 8, 2025BloodOpen Access

Paradoxical urban mortality penalty in sickle cell disease: A 20-year national analysis revealing age-dependent disparities

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Authors

SASamuel Anim

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Overview

Analysis identifies urban mortality disparities in sickle cell disease, suggesting rural settings may offer better outcomes.

Key Points

  • To investigate mortality patterns among sickle cell disease patients in urban versus rural areas, emphasizing age-related differences.
  • Analyzed data from the CDC's WONDER database for SCD-related deaths from 2000 to 2020.
  • Calculated age-adjusted mortality rates and incidence rate ratios using Poisson regression.
  • Stratified analysis by age and sex, applying a metro-non-metro hierarchy.
  • Identified 10,647 SCD deaths during the study period.
  • Highest mortality observed in large-central metros, with a 37% lower rate in rural counties.
  • Urban mortality penalty intensified with age, nearly doubling for adults ≥45 compared to rural counterparts.

Cite This Study

Samuel Anim (2025) studied this question.

synapsesocial.com/papers/69362f7d4fa91c937236e49bhttps://doi.org/10.1182/blood-2025-1170
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Also Consider

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  1. 1Disparities in sickle cell disease related mortality in the US-Mexico border region from 1999 to 2020: A CDC wonder Study2025
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  3. 3Social Vulnerability and Sickle Cell Disease Mortality in the US2024 · 12 citations
  4. 4Mortality trends and socioeconomic inequalities in sickle cell disease in Colombia, 2012–2023: a population-based study2026
  5. 5Geographic and temporal trends in sickle cell disease hospitalizations in New York State2025