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This research characterizes the spectrum of KRAS mutations in histiocytic neoplasms and evaluates their response to MEK inhibitors.

December 8, 2025Blood

KRAS mutations in histiocytic neoplasms: Mutation spectrum and response to MEK inhibition

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Authors

BSBrinda H ShuklaMarwadi University PBPradeep BhambhvaniUniversity of Alabama at Birmingham ASAditi SahaUniversity of Alabama at Birmingham Hospital

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Implication

Retrospective analysis identifies KRAS mutation impact on treatment response in histiocytic neoplasms, suggesting variability in effectiveness of trametinib.

Key Points

This research characterizes the spectrum of KRAS mutations in histiocytic neoplasms and evaluates their response to MEK inhibitors.
Conducted a retrospective review of patients with histiocytic neoplasms evaluated at Mayo Clinic and University of Alabama at Birmingham.
Included patients with identified KRAS mutations through next-generation sequencing.
Response assessment followed the Histiocyte Society consensus guidelines.
Identified 23 patients with KRAS mutations, predominantly female, with median age of 61 years.
The most frequent KRAS variants included p.K117N and p.G12D, with varying mutation distribution by disease type.
75% overall response rate to MEK inhibitors was observed, with distinctions among mutation subtypes.

Cite This Study

Shukla et al. (2025) studied this question.

synapsesocial.com/papers/69362f7d4fa91c937236e4e6 https://doi.org/10.1182/blood-2025-6760

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Implication

Retrospective analysis identifies KRAS mutation impact on treatment response in histiocytic neoplasms, suggesting variability in effectiveness of trametinib.

KRAS mutations in histiocytic neoplasms: Mutation spectrum and response to MEK inhibition

Discussion

Member takes

Implication

Key Points

Cite This Study

KRAS mutations in histiocytic neoplasms: Mutation spectrum and response to MEK inhibition

Discussion

Member takes

Implication

Key Points

Cite This Study

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