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December 8, 2025BloodOpen Access

Exploring molecular heterogeneity and clonal evolution in chronic myelomonocytic leukemia via single-cell transcriptome sequencing

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Authors

JZJie ZhouTongji UniversityHWHao WuHarbin Medical UniversityALAibin LiangTongji University

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Overview

Single-cell transcriptome sequencing uncovers clonal evolution features and marker genes in chronic myelomonocytic leukemia, suggesting new targets for therapy.

Key Points

  • To explore the molecular heterogeneity and clonal evolution in chronic myelomonocytic leukemia (CMML) using single-cell transcriptome sequencing.
  • Applied single-cell transcriptome sequencing on bone marrow aspirates from 5 CMML patients and 4 healthy donors.
  • Performed dimensionality reduction and clustering analysis.
  • Conducted differential gene expression analysis, GO, and KEGG pathway enrichment.
  • Identified 13 distinct cellular clusters with significant compositional differences between CMML and healthy controls.
  • Detected 1,866 differentially expressed genes in CMML, including marker genes relevant to clonal evolution.
  • Revealed significant enrichment in biological processes such as neutrophil degranulation and pathways like B cell receptor signaling.

Cite This Study

Zhou et al. (2025) studied this question.

synapsesocial.com/papers/69362f7d4fa91c937236e4f3https://doi.org/10.1182/blood-2025-6763
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Molecular-Based Ecosystem to Improve Personalized Medicine in Chronic Myelomonocytic Leukemia2026 · 4 citations
  2. 2Interim Results of the CMML scrna-seq atlas: GMP skewing is independently associated with overall survival in CMML.2025
  3. 3Single-cell sequencing analysis of multiple myeloma heterogeneity and identification of new theranostic targets2024
  4. 4Chronic myelomonocytic leukemia without increased classical monocyte subsets exhibits a distinct genetic profile, including frequent CBL mutations2026
  5. 5Acquisition of CLL-like epigenetic and transcriptomic states in low-count MBL2025