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December 8, 2025Blood

Interim Results of the CMML scrna-seq atlas: GMP skewing is independently associated with overall survival in CMML.

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Authors

MBMaria E. BalasisMoffitt Cancer CenterSMSean MurphyCardiac ImagingNDNathalie DroinCentre National de la Recherche Scientifique

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Overview

Interim analysis reveals chronic myeloid neoplasms have altered HSPC ratios, indicating impacts on survival.

Key Points

  • To investigate the relationship between HSPC composition and survival in chronic myeloid neoplasms using scRNA-seq data.
  • 39 single-cell RNA expression profiles derived from 113 CD34-enriched CMML BMNC samples analyzed
  • Utilized 10x Genomics GEM-X chemistry for sequencing
  • Data processed using Cell Ranger and annotated with Seurat
  • Survival analysis performed utilizing KM curves, log-rank tests, and Cox regression.
  • Massive reshaping of HSPC composition was identified, with significant expansions of GMP and depletions of B-cell progenitors.
  • HSC and MEP expansions associated with improved survival, while GMP expansions linked to inferior survival outcomes.
  • GMP/HSC and GMP/MEP ratios proved independently prognostic when accounting for clinical and genetic features.

Cite This Study

Balasis et al. (2025) studied this question.

synapsesocial.com/papers/69362f4e4fa91c937236d858https://doi.org/10.1182/blood-2025-3840
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