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March 22, 2024Cancer Research

Multiomic Profiling of Precursor Progression in Multiple Myeloma

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Authors

RCRafael Renatino CanevaroloMoffitt Cancer CenterPSPraneeth SudalaguntaMoffitt Cancer CenterMSMaria João SilvaUniversity of Trás-os-Montes and Alto Douro

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Implication

Single-cell multiomic analysis reveals epigenetic alterations across multiple myeloma precursor stages, suggesting polycomb complex hijacking drives disease progression.

Key Points

  • Epigenetic dysregulation and polycomb complex alterations drive the evolutionary transition from precursor states like MGUS to active multiple myeloma.
  • Single-cell multiomics across 10 bone marrow samples revealed H3K27me3 gene clusters as the sole drivers exhibiting significant chromatin accessibility changes.
  • Hijacking of the polycomb complex represents a shared biological vulnerability across precursor stages, highlighting a therapeutic target to halt progression.

Cite This Study

Canevarolo et al. (2024) studied this question.

synapsesocial.com/papers/68e72e1db6db6435876a72d0https://doi.org/10.1158/1538-7445.am2024-4406
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Abstract 6848: Analysis of the bone microenvironment cells by single cell transcriptomics reveals altered features in multiple myeloma patients compared to pre-malignant monoclonal gammopathies2024
  2. 2Single-cell DNA sequencing uncovers synergistic co-mutations in multiple myeloma2025
  3. 3Single-cell transcriptomics reveals proliferative, immune-evasive, and bone marrow–independent transcriptional programs in extramedullary multiple myeloma.2025
  4. 4Multi-omics reveals immune features in immune and non-immune cells, an IFN-γ/IFN-α-B2M positive feedback loop, and targeted metabolic therapy in multiple myeloma2025
  5. 5Abstract 6881: Investigating the role of post-transplant bone marrow immune dysregulation in multiple myeloma2024