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December 8, 2025BloodOpen Access

Single-cell DNA profiling unveils clonal evolution and identifies mechanisms of therapeutic resistance and progression in monoclonal gammopathies

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Authors

BABeñat AricetaSVSaioa VicenteJMJesús F. San Miguel

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Overview

Single-cell DNA sequencing shows clonal evolution and therapeutic resistance in monoclonal gammopathies, suggesting implications for precision medicine.

Key Points

  • The study aims to understand clonal evolution and therapeutic resistance mechanisms in monoclonal gammopathies through single-cell analysis.
  • Single-cell DNA sequencing performed on CD138+ cells isolated from bone marrow aspirates of patients with monoclonal gammopathies.
  • Integration of somatic mutations, copy number variations, and immunophenotypes across various disease stages.
  • Analysis of genomic data alongside surface protein expression to correlate with clinical outcomes.
  • Detected substantial genomic heterogeneity across disease stages and treatment responses.
  • Identified early driver mutations and complex copy number variations in early disease stages such as MGUS and SMM.
  • Noted significant associations between GPRC5D and BCMA mutations with limited responses to targeted therapies.

Cite This Study

Ariceta et al. (2025) studied this question.

synapsesocial.com/papers/69362f3a4fa91c937236d3f2https://doi.org/10.1182/blood-2025-7445
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