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December 8, 2025BloodOpen Access

Subclonal genomic heterogeneity shapes immune crosstalk and clinical outcomes in multiple myeloma

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Authors

SLSihong LiKLKelvin H. LeeRARafat Abonour

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Overview

Analysis reveals therapeutic resistance in multiple myeloma, suggesting genomic landscape impacts immune cell interactions and prognosis.

Key Points

  • This research aims to explore how subclonal genomic heterogeneity in multiple myeloma affects immune interactions and clinical outcomes.
  • Analyzed samples from smoldering and newly diagnosed multiple myeloma patients using multiomic techniques.
  • Identified subclones using single-cell RNA and ATAC sequencing data.
  • Examined immune cell interactions through ligand-receptor analyses and survival analysis of genomic alterations.
  • Identified 79 subclones in newly diagnosed multiple myeloma with complex copy number alterations.
  • Found significant survival differences based on co-occurring genomic alterations, notably Gain1q and Del13q.
  • Noted lower interactions of Gain1q subclones with CD8T cells, impacting therapeutic outcomes.

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/69362f484fa91c937236d6e3https://doi.org/10.1182/blood-2025-5732
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Single-cell DNA sequencing uncovers synergistic co-mutations in multiple myeloma2025
  2. 2Inference of genomic lesions from single-cell RNAseq in myeloma improves functional intra- and inter-clonal analysis2024 · 3 citations
  3. 3Single-cell DNA profiling unveils clonal evolution and identifies mechanisms of therapeutic resistance and progression in monoclonal gammopathies2025 · 1 citations
  4. 4Abstract 4406: Single cell multiomic analysis reveals how genomic, epigenomic and transcriptomic events drive progression of multiple myeloma precursor states2024
  5. 5Single-cell sequencing analysis of multiple myeloma heterogeneity and identification of new theranostic targets2024