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December 8, 2025BloodOpen Access

Identification of persister cells and evolution of tumor clones during immunotherapy and at minimal residual disease timepoints decoded by single-cell whole-genome sequencing in multiple myeloma

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Authors

CKCatherine M. KetchamSMSophie MagidsonSMShonali Midha

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Overview

Single-cell whole-genome sequencing reveals tumor evolution and persistent cells in multiple myeloma during immunotherapy, suggesting implications for treatment strategies.

Key Points

  • This research aims to explore the role of tumor cells in relapse and minimal residual disease during immunotherapy in multiple myeloma.
  • Analyzed tumor plasma cells from patients undergoing various therapies using single-cell whole-genome sequencing.
  • Utilized fluorescence-activated cell sorting for cell isolation from bone marrow and peripheral blood samples.
  • Performed phylogenetic analysis of tumor cell evolution across multiple treatment timepoints.
  • Identified persistent tumor cells during immunotherapy associated with minimal residual disease.
  • Noted dynamics in CD38 expression in tumors and its implications for therapy selection.
  • Revealed subclonal tumor heterogeneity and mutations, suggesting evolution of resistant clones over time.

Cite This Study

Ketcham et al. (2025) studied this question.

synapsesocial.com/papers/69362f444fa91c937236d5ffhttps://doi.org/10.1182/blood-2025-3930
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  5. 5The dynamic landscape of immune environment for MM patients receiving T cell redirectiing therapies2025