What question did this study set out to answer?

To explore immune and tumor interactions influencing treatment response and disease progression in multiple myeloma.

December 9, 2025Blood Cancer DiscoveryOpen Access

Longitudinal profiling of tumor and immune compartments uncovers patterns of dysregulation and associations with response in multiple myeloma

View Full Paper

Ask AI

Bookmark

Authors

DODenis OhlstromGeorgia Institute of Technology WPWilliam PilcherGeorgia Institute of Technology MMMarina E. MichaudEmory Healthcare

Discussion

Member takes

Implication

Longitudinal analyses demonstrate enhanced treatment response linked to B cell dynamics in multiple myeloma, suggesting immune profiling may inform therapy.

Key Points

To explore immune and tumor interactions influencing treatment response and disease progression in multiple myeloma.
Conducted multi-omics profiling of 243 bone marrow samples from 102 patients
Performed CD138neg single-cell RNA sequencing and CD138pos bulk RNA and whole-genome sequencing
Analyzed immune signaling pathways and cell populations over time post-treatment.
Interferon-γ signaling associated with impaired T cell memory after autologous stem cell transplant
Naïve B cell abundance was linked to improved progression-free survival (HR = 0.48)
At progression, increased cancer-testis antigens were observed, alongside B cell depletion and T-cell exhaustion.

Cite This Study

Ohlstrom et al. (2025) studied this question.

synapsesocial.com/papers/69401d732d562116f28f951b https://doi.org/10.1158/2643-3230.bcd-25-0205

View Full Paper

Ask AI

Bookmark

December 9, 2025Blood Cancer DiscoveryOpen Access

Longitudinal profiling of tumor and immune compartments uncovers patterns of dysregulation and associations with response in multiple myeloma

View Full Paper

Ask AI

Bookmark

Authors

DODenis OhlstromGeorgia Institute of Technology WPWilliam PilcherGeorgia Institute of Technology MMMarina E. MichaudEmory Healthcare

Discussion

Member takes

Implication

Longitudinal analyses demonstrate enhanced treatment response linked to B cell dynamics in multiple myeloma, suggesting immune profiling may inform therapy.

Key Points

To explore immune and tumor interactions influencing treatment response and disease progression in multiple myeloma.
Conducted multi-omics profiling of 243 bone marrow samples from 102 patients
Performed CD138neg single-cell RNA sequencing and CD138pos bulk RNA and whole-genome sequencing
Analyzed immune signaling pathways and cell populations over time post-treatment.
Interferon-γ signaling associated with impaired T cell memory after autologous stem cell transplant
Naïve B cell abundance was linked to improved progression-free survival (HR = 0.48)
At progression, increased cancer-testis antigens were observed, alongside B cell depletion and T-cell exhaustion.

Cite This Study

Ohlstrom et al. (2025) studied this question.

synapsesocial.com/papers/69401d732d562116f28f951b https://doi.org/10.1158/2643-3230.bcd-25-0205

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

View Full Paper

Ask AI

Bookmark