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December 8, 2025Blood

An immune proteomic atlas of 300 million bone marrow cells reveals prognostic cell states in multiple myeloma

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Authors

WPWilliam PilcherGeorgia Institute of TechnologyEGEdgar Gonzalez‐KozlovaMount Sinai HospitalTKTaxiarchis KourelisMayo Clinic

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Implication

Large CyTOF study identifies immune cell types linked to clinical outcomes in multiple myeloma, suggesting new therapeutic targets.

Key Points

  • This research investigates the immune landscape in the tumor microenvironment of multiple myeloma to identify prognostic markers.
  • Conducted a CyTOF-based immune profiling study with >300 million bone marrow immune cells.
  • Analyzed >1,000 bone marrow samples from ~700 newly diagnosed multiple myeloma patients.
  • Utilized a harmonized protocol with a 41-antibody CyTOF panel across five academic centers.
  • Identified major immune compartments including neutrophils, CD4 T cells, and B cells among others.
  • Higher proportions of naïve B cells, plasmablasts, and γδ T cells were associated with improved overall survival.
  • Elevated neutrophil proportions correlated with inferior overall survival and shorter progression-free survival.

Cite This Study

Pilcher et al. (2025) studied this question.

synapsesocial.com/papers/69362f764fa91c937236e42chttps://doi.org/10.1182/blood-2025-5801
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Longitudinal profiling of tumor and immune compartments uncovers patterns of dysregulation and associations with response in multiple myeloma2025
  2. 2CyTOF profiling of bone marrow immune dynamics across myeloma stages2025 · 3 citations
  3. 3A single-cell atlas characterizes dysregulation of the bone marrow immune microenvironment associated with outcomes in multiple myeloma2024 · 14 citations
  4. 4Multi-omics reveals immune features in immune and non-immune cells, an IFN-γ/IFN-α-B2M positive feedback loop, and targeted metabolic therapy in multiple myeloma2025
  5. 5The Prognostic Value of Combined Complete Blood Count and Immune Cell Profiling in Patients with Multiple Myeloma Treated with Chemotherapy Sequential Transplantation2026