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December 8, 2025Blood

Safety and efficacy of consolidation-Phase blinatumomab in newly diagnosed B-cell acute lymphoblastic leukemia : A systematic review and meta-analysis

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Authors

CKChandra KakaralaSASyeda Wania AmjadAKAtulya Aman Khosla

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Overview

Systematic review shows blinatumomab improves complete response rates in newly diagnosed B-cell acute lymphoblastic leukemia, highlighting its favorable safety profile.

Key Points

  • To evaluate the efficacy and safety of blinatumomab in the consolidation phase of newly diagnosed B-ALL.
  • Systematic review and meta-analysis of clinical trials and observational studies
  • Evaluated response metrics: overall response rate and complete response
  • Analyzed data using the Der Simonian-Laird random effects model
  • Pooled overall response rate was 96.4%
  • Pooled complete response rate was 92.7%
  • 6.8% of patients experienced treatment-related adverse events leading to discontinuation
  • Treatment-related mortality rate was 1.4%

Cite This Study

Kakarala et al. (2025) studied this question.

synapsesocial.com/papers/69362f7f4fa91c937236e50fhttps://doi.org/10.1182/blood-2025-6871
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1“upfront use of blinatumomab in adolescents and adults with Philadelphia Chromosome–Negative B-cell acute lymphoblastic leukemia: A systematic review and proportional meta-analysis”2025
  2. 2FDA Approval Summary: Blinatumomab for the Treatment of B-cell Precursor Acute Lymphoblastic Leukemia in the Consolidation Phase of Multiphase Chemotherapy2025 · 8 citations
  3. 3Data from FDA Approval Summary: Blinatumomab for the Treatment of B-Cell Precursor Acute Lymphoblastic Leukemia in the Consolidation Phase of Multiphase Chemotherapy2025
  4. 4Blinatumomab consolidation in high-risk Philadelphia chromosome-negative B-cell acute lymphoblastic leukemia in adults: Final report of the graall-2014/b-QUEST study.2025
  5. 5Blinatumomab vs. chemotherapy in pediatrics B-cell ALL: A meta-analysis of randomized controlled trials2025