What question did this study set out to answer?

This analysis aims to evaluate survival outcomes based on degrees of hematologic recovery in pediatric acute myeloid leukemia.

December 8, 2025BloodOpen Access

Comparable efficacy of CR, CRh, and CRi in pediatric acute myeloid leukemia: A report from the Japan Children's Cancer Group

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Retrospective analysis shows comparable outcomes for CRh and CRi in pediatric AML, indicating treatment validity.

This analysis aims to evaluate survival outcomes based on degrees of hematologic recovery in pediatric acute myeloid leukemia.
Analyzed pediatric AML patients under 18 from two clinical trials in Japan.
Initial induction therapies included standard-dose cytarabine or high-dose cytarabine based on randomization.
Treatment responses assessed after induction therapy according to ELN criteria.
313 patients achieved complete remission (CR), 352 CR with partial hematologic recovery (CRh), and 14 with CR with incomplete hematologic recovery (CRi).
Event-free survival (EFS) probability for CR was 63.4%, comparable with CRh and CRi.
MLFS and non-remission (NR) groups had significantly worse EFS and overall survival (OS).

Niwa et al. (2025) studied this question.

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