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December 8, 2025Blood

RAG1/2 expression in follicular lymphoma marks candidate precursor cells of high-grade B cell lymphoma with MYC and BCL2 rearrangements

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Authors

GMGaia MorelloVPVilma PellegriniMPMaurilio Ponzoni

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Overview

Analysis reveals RAG1/2 expression in follicular lymphoma may identify precursor cells for high-grade B cell lymphoma with MYC and BCL2 rearrangements, suggesting new targets for intervention.

Key Points

  • To identify RAG1/2-expressing precursor cells in follicular lymphoma and their association with high-grade B cell lymphoma.
  • Analyzed 10 cases of follicular lymphoma and their corresponding high-grade B cell lymphoma counterparts.
  • Used RNA scope for RAG1/2 transcript detection and DNA FISH for t(14;18) mapping.
  • Assessed immunohistochemistry for LMO2 to explore the relation of RAG+ cells to germinal center reactions.
  • RAG1/2 transcripts were found in a distinct subset of LMO2+BCL2+ t(14;18)+ cells in 5 of 6 FL cases.
  • Two cases showed co-expression of IGK and IGL light chains in follicular lymphoma prior to high-grade transformation.
  • Identified a unique population of RAG-expressing cells as potential precursors for high-grade B cell lymphoma.

Cite This Study

Morello et al. (2025) studied this question.

synapsesocial.com/papers/69362f7f4fa91c937236e57dhttps://doi.org/10.1182/blood-2025-3534
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1B cell receptor silencing reveals the origin of high-grade B cell lymphomas with MYC and BCL2 rearrangements2024 · 1 citations
  2. 2Stepwise engineering of human germinal center B cells to model dark zone high-grade B cell lymphoma driven by sequential BCL2 and MYC deregulation2025
  3. 3Clinical outcomes, patterns of relapse and molecular landscape of advanced stage High Grade B-cell Lymphoma2026
  4. 4B-cell Receptor Silencing Reveals the Origin and Dependencies of High-Grade B-cell Lymphomas with <i>MYC</i> and <i>BCL2</i> Rearrangements2025 · 6 citations
  5. 5Overlapping Gene Expression and Molecular Features in High-Grade B-Cell Lymphoma2024