What type of study is this?

This is a Pre-Registered Trial study (also classified as: Systematic Review).

What question did this study set out to answer?

The study aims to evaluate the real-world effectiveness and safety of Pola-R-CHP in untreated DLBCL.

December 8, 2025Blood

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Systematic literature review assesses real-world data for Pola-R-CHP in DLBCL, highlighting efficacy and adverse events.

The study aims to evaluate the real-world effectiveness and safety of Pola-R-CHP in untreated DLBCL.
Conducted a systematic literature review adhering to PRISMA and Cochrane guidelines.
Searched MEDLINE®, Embase®, and Evidence-Based Medicine Reviews for relevant studies.
Included single- and multi-arm studies assessing Pola-R-CHP treatment in adults with DLBCL.
Identified 34 publications reporting findings on 2,813 DLBCL patients treated with Pola-R-CHP.
Objective response rate was 92%, with a complete response rate of 80%.
The 12-month progression-free survival rate was 84%, with 68% for patients over 80 years.

Li et al. (2025) studied this question.

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