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December 8, 2025Blood

Real-world chronic lymphocytic leukemia (CLL)–specific biomarker testing patterns and frontline treatment patterns in patients with CLL/small lymphocytic lymphoma (SLL)

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Authors

WYWilliam YeGMGregory A. Maglinte

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Overview

Observational study reveals low biomarker testing rates in chronic lymphocytic leukemia, suggesting improved treatment decisions are needed.

Key Points

  • This research aims to examine real-world biomarker testing and frontline treatment patterns for chronic lymphocytic leukemia (CLL).
  • Retrospective observational study conducted at Baylor Scott & White Health
  • Included patients diagnosed with CLL who initiated frontline treatment between 2020 and 2024
  • Examined biomarker test orders, demographic factors, and treatment regimens
  • 327 patients analyzed, median age 73 years, majority non-Hispanic White and urban dwellers
  • 42.8% had FISH tests, low rates for TP53 (3.4%) and IGHV (8.0%) tests
  • Patients with FISH testing more likely to receive BTK inhibitor regimens (60.7% vs 48.7%) compared to those without testing

Cite This Study

Ye et al. (2025) studied this question.

synapsesocial.com/papers/69362f7f4fa91c937236e5dbhttps://doi.org/10.1182/blood-2025-8077
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Impact of testing for genetic markers on treatment selection and clinical outcomes among patients with chronic lymphocytic leukemia2025
  2. 2A genomic analysis of patients with chronic lymphocytic leukemia treated with fixed duration therapy in a first-line setting in alberta, Canada2025
  3. 3Real-world comparison of time to next treatment for patients with high-risk CLL/SLL in first line of treatment.2024
  4. 4Chemo ± immunotherapy remains utilized for chronic lymphocytic lymphoma in the real-world practice: Unmet needs, treatment patterns, and age disparities in the United States2025
  5. 5An international view on the current approaches to frontline chronic lymphocytic leukemia therapy2025