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December 8, 2025BloodOpen Access

Baseline T-cell fitness and subtype-specific CD19 loss as drivers of blinatumomab resistance in B-ALL

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Authors

SBSonja BendigALAnna LaquaMSMonika Szczepanowski

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Overview

Retrospective analysis reveals T-cell exhaustion and CD19 loss may drive treatment resistance in B-ALL patients.

Key Points

  • This research aims to identify predictive markers of T-cell functionality associated with blinatumomab resistance in B-ALL.
  • Retrospective analysis of 72 bone marrow samples from 36 adult Ph-negative B-ALL patients
  • Utilization of multiparametric spectral flow cytometry and single-cell RNA sequencing
  • Group classification based on post-treatment B-cell status to evaluate T-cell functionality
  • Patients with B-cell aplasia had distinct T-cell profiles compared to those with B-cell persistence
  • Loss of CD19 expression was noted predominantly in specific B-ALL subtypes
  • Lower levels of naïve CD8+ T cells and increased exhaustion markers predicted T-cell dysfunction under blinatumomab

Cite This Study

Bendig et al. (2025) studied this question.

synapsesocial.com/papers/69362f7f4fa91c937236e5e8https://doi.org/10.1182/blood-2025-32
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