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December 8, 2025BloodOpen Access

Comparative safety and effectiveness of direct oral anticoagulants and low-molecular weight heparin in patients with venous thromboembolism and cancer in europe

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The study aimed to evaluate the comparative safety and effectiveness of direct oral anticoagulants and low-molecular weight heparin in patients with cancer-associated venous thromboembolism.
Utilized datasets from national registers in Sweden, Finland, Norway, the UK, and Germany.
Identified treatment-naive adult patients with venous thromboembolism and cancer treated with DOACs or LMWH.
Applied inverse probability of treatment weighting to account for confounding in the comparisons.
Identified 34,687 LMWH users and several DOAC users across five countries before IPTW.
At 6 months, apixaban showed a lower risk of overall bleeding compared to LMWH, while rivaroxaban showed similar risks for overall and GI bleeding.
The risk of ICH was significantly lower for rivaroxaban.

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Implication

Observational study finds apixaban reduces overall bleeding in patients with venous thromboembolism and cancer, indicating risks differ among treatments.

Cite This Study

Brodin et al. (2025) studied this question.

synapsesocial.com/papers/69362f7f4fa91c937236e5e9 https://doi.org/10.1182/blood-2025-24

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Implication

Observational study finds apixaban reduces overall bleeding in patients with venous thromboembolism and cancer, indicating risks differ among treatments.

Comparative safety and effectiveness of direct oral anticoagulants and low-molecular weight heparin in patients with venous thromboembolism and cancer in europe

Key Points

Discussion

Implication

Cite This Study

Comparative safety and effectiveness of direct oral anticoagulants and low-molecular weight heparin in patients with venous thromboembolism and cancer in europe

Key Points

Discussion

Implication

Cite This Study

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