Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 8, 2025Blood

Chemotherapy selects for myeloid subclones in multiple subtypes of B-cell acute lymphoblastic leukemia

View Full Paper
Ask AI
Bookmark
Share

Authors

CCChangya Chen

Discussion

Loading...

Member takes

Overview

Comprehensive profiling demonstrates that chemotherapy enriches myeloid subclones in B-cell ALL, suggesting implications for blinatumomab efficacy.

Key Points

  • This research investigates the role of lineage infidelity in resistance mechanisms within B-cell acute lymphoblastic leukemia.
  • Utilized multiomic profiling including single-cell RNA sequencing, single-cell DNA-seq, and flow cytometry.
  • Analyzed paired pediatric B-ALL samples collected at diagnosis and end of induction therapy.
  • Sorted CD19⁻ blasts and transplanted them into immunodeficient NSG mice to assess functional potential.
  • Documented presence of myeloid-like subclones at minimal residual disease in several B-cell ALL subtypes.
  • Validated presence of mutations (PAX5) in these subclones, confirming clonal relationships to bulk leukemia.
  • Identified that these subclones showed reduced expression of canonical B-cell markers, impacting treatment response.

Cite This Study

Changya Chen (2025) studied this question.

synapsesocial.com/papers/69362f7f4fa91c937236e5eehttps://doi.org/10.1182/blood-2025-35
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Tracking The Molecular Dynamics of Lineage Switch Under CD19 CAR-T Treatment in Non-KMT2A Rearranged B-ALL Patients2024
  2. 2Abstract 5248: Single-cell multi-omics reveals co-mutation of <i>TP53</i> and epigenetic gene driving myeloid transformation in B-ALL following CAR-T therapy2026
  3. 3Multiple Lineage Switches in a Pediatric Case With a <i>KMT2A::AFF1</i>‐Positive Acute Lymphoblastic Leukemia: How Cell Plasticity Induces Immunotherapy Failure2025 · 1 citations
  4. 4Multi-omic analysis of early minimal residual disease identifies functional and transcriptomic signatures of treatment resistance in pediatric B-cell acute lymphoblastic leukemia2025
  5. 5Abstract 7012: Single-cell multi-omics identifies MRD-associated Tr1-like CD4 cells in B-ALL2026