Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 10, 2025Pediatric Blood & Cancer

Multiple Lineage Switches in a Pediatric Case With a KMT2A::AFF1‐Positive Acute Lymphoblastic Leukemia: How Cell Plasticity Induces Immunotherapy Failure

View Full Paper
Ask AI
Bookmark
Share

Authors

LNLuca Lo NigroMAMarta ArrabitoECEmanuela Cannata

Discussion

Loading...

Member takes

Overview

Case study reveals lineage switches in a pediatric patient with KMT2A::AFF1-positive leukemia, highlighting immunotherapy challenges.

Key Points

  • The patient experienced multiple lineage switches between ALL and AML, complicating treatment efforts.
  • Despite undergoing chemotherapy and hematopoietic stem cell transplantation, immunotherapy was less effective due to cell plasticity.
  • Characterizing the cell-of-origin is critical for developing targeted therapies in such cases.
  • Immunoglobulin/T-cell receptor rearrangements persisted, indicating a resilient leukemic clone.

Cite This Study

Nigro et al. (2025) studied this question.

synapsesocial.com/papers/68c1a76954b1d3bfb60e05f7https://doi.org/10.1002/pbc.31950
View Full Paper
Ask AI
Bookmark
Share